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    Search for "cytochrome"

    Displaying results 1 to 4 out of 4

      Early Phase I to IIa 81%
      ... including allergic, hypertensive and hyperlipidemic subjects. Special panels of genotyped subjects such as poor metabolizers (PM) for a certain cytochrome isoenzyme are also available. CRS has access to various panels of healthy subjects, healthy subpopulations and patients .
      Size: 32 K - Created: 18-11-12 - Modified: 07-10-19 14:37
    Path: /Services/Early Phase I to IIa

      Special Populations 79%
      ... women as well as elderly volunteers is part of CRS’s standard routine. Genotyped Subjects: Over 3,000 healthy subjects are genotyped for the cytochrome P450 genes CYP2D6 (> 100 poor metabolizers), CYP2C9 (> 170 PM) and CYP2C19 (> 90 PM). Additional panels such as UGT1A1 characterisation are in ...
      Size: 32 K - Created: 18-11-12 - Modified: 02-08-19 10:27
    Path: /Expertise/Special Populations

      2000 – 2009 70%
      ... M, Rengelshausen J, Ding R, Riedel KD, Burhenne J, Weiss J, Thomsen T , Haefeli WE. Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir. Clin Pharmacol Ther 2006; 80(2):126-135. Sidharta PN, Wagner ... WK, Greenberg HE, Waldman SA, Curtis SP, Gottesdiener KM. The effects of modifying in vivo
      Size: 53 K - Created: 09-11-15 - Modified: 02-08-19 10:27
    Path: /Expertise/Published Expertise/2000 – 2009

      1990 – 1999 57%
      1990 – 1999 1999 Bachus R, Bickel U, Thomsen T , Roots I, Kewitz H. The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6. Pharmacogenetics 1999 ; 9:661-668. Dingemanse J, Halabi A , Kleinbloesem CH, Heinig R, Blume H. Pharmacokinetics and pharmacodynamics ...
      Size: 60 K - Created: 18-11-12 - Modified: 02-08-19 10:27
    Path: /Expertise/Published Expertise/1990 – 1999

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